Safe, all natural and water soluble ac-11® is a patent-protected, bioactive rainforest plant extract that helps the body to repair sun and environmental stress-related damage to DNA, and slow down the process of skin aging. ac-11® is the perfect joining of the rainforest’s secrets with the miracle of today’s advancements in phytonutrient science.
ac-11® derives from Uncaria tomentosa, a plant indigenous to the rainforest. ac-11® uses patented, wholly proprietary “aqueous hot water extraction” and purification process standardized to a minimum of 8% Carboxy Alkyl Esters (CAE) concentration.
Some of the more important studies, papers and articles about ac-11®:
A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidants
This study was conducted to review the DNA repair mechanisms and substances to enhance DNA repair to pave the way for rational and efficacious dermatologic therapies. The best treatment for skin cancer is prevention. Here in the study discusses the DNA repair Adjuvants of DNA Repair (Uncaria tomentosa) and Dimericine (T4 endonuclease V that is prepared in a liposome lotion. In conclusion, DNA repair adjuvants and anti-oxidants appear to be a viable means for enhancing health.
Emanuel, P., Scheinfeld, N.
Dermatology Online Journal
Reprinted with the permission of Dr. Noah Scheinfeld, M.D., J.D.
The Repair of CPDs (UV-Induced Damage) in Cell Cultures Over 24 hours Using Antibodies Against CPD.
Exposure to sunlight creates DNA damage in skin cells. By linking adjacent bases to form cyclobutane pryimidine dimers (CPD). This is primarily done with thymine-thymine type dimmers (tt-dimers) but other DNA base pair combinations are possible. Our body naturally repairs about 50% of sun damage within 24 hours. The result of this study shows DNA Repair Science significantly helps us to increase the repair to sun damaged cells/DNA. The repair increase at 24 hours was up to 70% to 75% compared with the untreated cells at 50%. These findings were quite consistent with the previous findings in the Estee Lauder study. It was, in part, based upon this research that initial Activar® and Aedre topical products were developed.
AGI Dermatics, Yarosh, D., nay, S. Confidential report #4. 2004.
Request from Optigenex
Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements
This human study was undertaken to study various effects of DNA repair Science when combined with other synergistic ingredients which include zinc, niacinamide, and standardized mushroom extracts. After 30 days of taking this oral supplement the participant reported reduced pain, reduce fatigue, weight loss, along with a measured decreased in DNA damage and increase in DNA repair. One of the means used to measure increased DNA repair was the measurement of serum protein thiol.
R.W. Pero, A. Amiri, Y. Sheng, M. Welther, M. Rich
Phytomedicine 12 (2005) 255–263; Received 28 March 2003; accepted 8 January 2004
Comparison of a broad spectrum anti-aging nutritional supplement with and without the addition of a DNA repair extract
The intent of this human study was to examine the DNA repair effects of a broad spectrum multi-vitamin, with and without the addition of DNA Repair. it is well known that a diet rich in vitamins and Phytonutrients is advantageous to health and provide support for healthy aging. Both formulas studied showed an improved ability to reduce oxidative stress and DNA damage. However the DNA Repair Science based formula showed a clear enhancement of these effects plus a much stronger ability to enhance the natural DNA repair process. The two formulations were compared using four intermediate end point biomarkers: 8-OH guanine DNA adducts, serum thiols, and interleukins 1a and 1. Again, the DNA Repair based formulation was much more effective at enhancing the natural cellular DNA repair process.
Pero, R.W., Giampapa, V., Vodjani, A.
Journal of Anti-Aging Medicine; Volume 5, Number 4, 2002
Historical development of Uncaria preparations and their related bioactive components
DNA Repair history and scientific research is truly changing the way clinical nutrition is being viewed as it relates to the bioactive ingredients identified as CAEs. Examples include: anti-inflammation, nuclear fraction kappa beta (NF-kB) inhibition, and immune enhancement. The list has been documented and studied to include many more benefits. Concepts discussed in this study could revolutionize how we treat most illnesses since their origins would have in common basic metabolic mechanisms that regulate energy, plus hormone and protein synthetic events. The data presented provides strong evidence that DNA Repair contributes to human nutritional enhancement as a dietary supplement based upon its high content of QA and QAEs™.
Editor: Thomas, A.
DNA Damage Repair, Repair Mechanisms and Aging, 2010; 10: 223-236
DNA Repair, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo
DNA Repair significantly prolongs lymphocyte survival and functionality in vivo. The number of surviving and functional lymphocytes is clearly an immune system benefit in humans. It appears that the accumulative of lymphocytes in the DNA Repair recipients is due to the anti-oxidative, anti-inflammatory, and DAN repair benefits associated with DNA Repair. The test subjects used DNA Repair daily for 63 days. The immune enhancement was clearly observable. Four weeks after stopping the use of DNA Repair the immune benefits went away and the subjects returned to their prior base line.
Åkesson, C., Pero, R.W., Ivars, F.
Phytomedicine 10: 23–33 (2003)
An extract of Uncaria tomentosa inhibiting cell division and NF-kB activity without inducing cell death
DNA Repair inhibits cancer division and cell proliferation, along with improved responses to inflammation. This study provides direct evidence that DNA Repair inhibits NF-kB activity and it is due to this mode of action that DNA Repair, in part, causes the inhibition of cancer cell division and proliferation. The ability of DNA Repair to inhibit cancer cell division was also shown to not be caused by toxicity or apoptosis (programmed cell death), but by an unknown mechanism.
Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology 3 (2003) 1889–1900
Quinic acid is a biologically active component of the Uncaria tomentosa extract DNA Repair
One of the main carboxy akyl esters (CAE™) are quinic alkyl esters (QAEs™) this study clearly identifies quinic acid (QAEs™) as a potent biologically active component that is found in high concentrations in DNA repair. Various endpoints were studied and compared with prior DNA Repair studies, The QA equivalents (esters, slats, and chelates) found in DNA repair were shown to have much greater synergistic biological activity than QA alone. The natural synergy of all the CAEs found in DNA repair were found to be more active than any of its isolated components. Due to this discovery 3 additional patents have now been awarded.
Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology 5 (2005) 219–229