Read what our customers are saying about Natural DNA Repair with ac-11®
My devotion to total wellness allows me to impact thousands of people through safe and effective natural modalities… ac-11 is superior to anything available today… it has the clinical backing demonstrating its ability to repair our cellular DNA.
I have had a more profound change in my energy level in 2 weeks taking DNA Life Caps than I’ve had in 2 years working with a functional medicine doctor. Something wonderful is going on. I love this product!
The DNA Life Caps are the best supplement I have ever taken. I have been struggling with my energy level for a long time. Now my energy levels are great all day since I started taking this product! I feel strong and focused.
I am approaching 78 and the ac-11 capsules made a huge difference in my life, including more energy. My friends also said I looked better, and at my age that is welcome news. If they can see the results, just imagine all the good things going on in my body that cannot be seen!
Natural DNA Repair’s products are 100% natural, chemical free, additive free; containing only organic and vegan ingredients, making our products earth friendly and kind to your body.
What is ac-11®?
ac-11® is a patented water soluble (alkaloid free) extract of Amazon Rainforest plant Uncaria tomentosa. ac-11® is standardized to a minimum of 8% Carboxy Alkyl Esters (CAE™) and 4% Quinic Alkyl Esters (QAE™). These are the primary and patented water-soluble actives.
ac-11® is relatively alkaloid free (<0.05%) and contains a new patented class of water soluble actives (CAE’s™ and QAE’s™) with proven anti-aging and DNA repair enhancement properties that have not been shown in other Uncaria tomentosa products or other plant based extracts.
Damage to DNA is a fundamental cause of aging and age-related disease as DNA repair mechanisms begin to fail with age, resulting in accumulation of damaged DNA throughout the body.
The medical and scientific community has linked enhanced DNA repair capacity with self-healing and in some cases, reversal of several health conditions.
Years of research and clinical studies in a variety of in-vitro, animal and human studies have proven Uncaria Tomentosa patented extract ac-11® ability to help the body repair its own DNA, normalize the expression of NF-kB in cells, thereby regulating cellular response to inflammation and a positive effect on lymphocytes, increasing their lifespan and enhancing the body’s immune system.
ac-11® derives from Uncaria tomentosa, a plant indigenous to the rainforest. ac-11® uses patented, wholly proprietary “aqueous hot water extraction” and purification process standardized to a minimum of 8% Carboxy Alkyl Esters (CAE) concentration.
Some of the more important studies, papers and articles about ac-11®:
This study was conducted to review the DNA repair mechanisms and substances to enhance DNA repair to pave the way for rational and efficacious dermatologic therapies. The best treatment for skin cancer is prevention. Here in the study discusses the DNA repair Adjuvants of DNA Repair (Uncaria tomentosa) and Dimericine (T4 endonuclease V that is prepared in a liposome lotion. In conclusion, DNA repair adjuvants and anti-oxidants appear to be a viable means for enhancing health.
Emanuel, P., Scheinfeld, N.
Dermatology Online Journal
Reprinted with the permission of Dr. Noah Scheinfeld, M.D., J.D.
Exposure to sunlight creates DNA damage in skin cells. By linking adjacent bases to form cyclobutane pryimidine dimers (CPD). This is primarily done with thymine-thymine type dimmers (tt-dimers) but other DNA base pair combinations are possible. Our body naturally repairs about 50% of sun damage within 24 hours. The result of this study shows DNA Repair Science significantly helps us to increase the repair to sun damaged cells/DNA. The repair increase at 24 hours was up to 70% to 75% compared with the untreated cells at 50%. These findings were quite consistent with the previous findings in the Estee Lauder study. It was, in part, based upon this research that initial Activar® and Aedre topical products were developed.
AGI Dermatics, Yarosh, D., nay, S. Confidential report #4. 2004.
Request from Optigenex
This human study was undertaken to study various effects of DNA repair Science when combined with other synergistic ingredients which include zinc, niacinamide, and standardized mushroom extracts. After 30 days of taking this oral supplement the participant reported reduced pain, reduce fatigue, weight loss, along with a measured decreased in DNA damage and increase in DNA repair. One of the means used to measure increased DNA repair was the measurement of serum protein thiol.
R.W. Pero, A. Amiri, Y. Sheng, M. Welther, M. Rich
Phytomedicine 12 (2005) 255–263; Received 28 March 2003; accepted 8 January 2004
The intent of this human study was to examine the DNA repair effects of a broad spectrum multi-vitamin, with and without the addition of DNA Repair. it is well known that a diet rich in vitamins and Phytonutrients is advantageous to health and provide support for healthy aging. Both formulas studied showed an improved ability to reduce oxidative stress and DNA damage. However the DNA Repair Science based formula showed a clear enhancement of these effects plus a much stronger ability to enhance the natural DNA repair process. The two formulations were compared using four intermediate end point biomarkers: 8-OH guanine DNA adducts, serum thiols, and interleukins 1a and 1. Again, the DNA Repair based formulation was much more effective at enhancing the natural cellular DNA repair process.
Pero, R.W., Giampapa, V., Vodjani, A.
Journal of Anti-Aging Medicine; Volume 5, Number 4, 2002
DNA Repair history and scientific research is truly changing the way clinical nutrition is being viewed as it relates to the bioactive ingredients identified as CAEs. Examples include: anti-inflammation, nuclear fraction kappa beta (NF-kB) inhibition, and immune enhancement. The list has been documented and studied to include many more benefits. Concepts discussed in this study could revolutionize how we treat most illnesses since their origins would have in common basic metabolic mechanisms that regulate energy, plus hormone and protein synthetic events. The data presented provides strong evidence that DNA Repair contributes to human nutritional enhancement as a dietary supplement based upon its high content of QA and QAEs™.
Editor: Thomas, A.
DNA Damage Repair, Repair Mechanisms and Aging, 2010; 10: 223-236
DNA Repair significantly prolongs lymphocyte survival and functionality in vivo. The number of surviving and functional lymphocytes is clearly an immune system benefit in humans. It appears that the accumulative of lymphocytes in the DNA Repair recipients is due to the anti-oxidative, anti-inflammatory, and DNA repair benefits associated with DNA Repair. The test subjects used DNA Repair daily for 63 days. The immune enhancement was clearly observable. Four weeks after stopping the use of DNA Repair the immune benefits went away and the subjects returned to their prior base line.
Åkesson, C., Pero, R.W., Ivars, F.
Phytomedicine 10: 23–33 (2003)
DNA Repair inhibits cancer division and cell proliferation, along with improved responses to inflammation. This study provides direct evidence that DNA Repair inhibits NF-kB activity and it is due to this mode of action that DNA Repair, in part, causes the inhibition of cancer cell division and proliferation. The ability of DNA Repair to inhibit cancer cell division was also shown to not be caused by toxicity or apoptosis (programmed cell death), but by an unknown mechanism.
Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology 3 (2003) 1889–1900
One of the main carboxy akyl esters (CAE™) are quinic alkyl esters (QAEs™) this study clearly identifies quinic acid (QAEs™) as a potent biologically active component that is found in high concentrations in DNA repair. Various endpoints were studied and compared with prior DNA Repair studies, The QA equivalents (esters, slats, and chelates) found in DNA repair were shown to have much greater synergistic biological activity than QA alone. The natural synergy of all the CAEs found in DNA repair were found to be more active than any of its isolated components. Due to this discovery 3 additional patents have now been awarded.
Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology 5 (2005) 219–229
U.S. Patent No. 6,039,949, Filed: February 1997, Issued March 2000: entitled “Method of Preparation and Composition of Water Soluble Extract of the Plant Species Uncaria.”
This patent is directed to a method for preparing and manufacturing an Uncaria Sp. extract and for its administration generally for pharmaceutical purposes.
U.S. Patent No. 6,238,675 B1, Filed November 1999, Issued May 2001: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory and Anti-Tumor Processes of Warm Blooded Animals.”
This patent is directed to the composition of the Uncaria species extract described in the ‘949 manufacturing patent; namely carboxy alkyl esters (“CAE”) and its pharmaceutical use for enhancement of immune, anti-inflammatory and anti-tumor responses.
U.S. Patent No. 6,361,805 B2, Filed April 2001, Issued March 2002: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”
This patent covers the administration and pharmaceutical use of a purified Uncaria species., standardized to CAE content, for DNA repair.
U.S. Patent No. 6,964,784 B2, Filed March 2002, Issued November 2005: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”
This patent covers the administration and pharmaceutical use of an isolated purified active ingredient of the Uncaria composition claimed in the ‘675 patent; namely, carboxy alkyl esters and, specifically, quinic acid alkyl ester.
U.S. Patent No. 7,579,023 B2, Filed November 2005, Issued August 2009: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”
This patent is directed to a method for isolating a bioactive component of the Uncaria extract. The claims are further directed to include; the isolated bioactive component being a carboxy alkyl ester, a quinic acid analog, a quinic acid lactone and/or in a pharmaceutical composition providing broader coverage for the active ingredients and therapeutic claims.
U.S. Patent No. 7,595,064 B2, Filed October 2004, Issued September 2009: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”
This patent is directed to a method of preparing and administering quinic acid or quinic acid salt to enhance DNA repair further identifying our active ingredients and application to DNA repair.
U.S. Patent No. 7,955,626 B2, Filed July 2009, Issued June 2011: entitled “Method for Enhancing the DNA Repair Process, Treating Disorders Associated with the DNA Repair Process, Enhancing Antitumor Response and Treating Disorders Associated with Anti-Tumor Response in Mammals by Administering Purified Quinic Acid and/or Carboxy Alkyl Ester.”
This patent is a continuation of the application that issued as U.S. Patent No.7,579,023. This patent covers the administration and pharmaceutical use of an isolated purified quinic acid alkyl ester or carboxy alkyl ester for DNA repair or treating disorders associated with a deficient DNA repair process.
U.S. Patent No. 7,947,312 B2, Filed May 2009, Issued May 2011: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”
This patent is a continuation of the application that issued as U.S. Patent No.7,595,064. This patent is directed to a method of enhancing DNA repair or treating disorders associated therewith by administering quinic acid or quinic acid salt where the quinic acid or salt thereof may form an ammonium salt or chelate thereof and further broadening the coverage of our actives and therapeutic claims.
US Patent No. 8,372,449 Issued February 12, 2013: Method For Enhancing The DNA Repair Process, Treating Disorders Associated With DNA Repair Process, Enhancing Anti-Tumor Response And Treating Disorders Associated With Anti-Tumor Response In Mammals By Administering Purified Quinic Acid And/Or Carboxy Alkyl Ester
This patent is directed toward a method of enhancing the response to tumor formation and/or growth in a mammal by administering a pharmaceutical composition comprising a purified isolated compound selected from the group consisting of quinic acid and quinic acid salt,where said quinic acid and quinic acid salt may form an ammonium salt and/or chelate in an amount to inhibit TNF-alpha production to induce apoptosis of white blood cells having a bioassay efficacy using IC50 in HL-60 cells of approximately 500 micrograms per milliliter or less where application is other than topical.
US Patent No. 8,372,448 Issued February 12, 2013: Method For Enhancing The DNA Repair Process, Treating Disorders Associated With DNA Repair Process, Enhancing Anti-Tumor Response And Treating Disorders Associated With Anti-Tumor Response In Mammals By Administering Purified Quinic Acid And/Or Carboxy Alkyl Ester
This patent is directed toward a method for enhancing the response to tumor formation and/or growth in a mammal by inhibiting TNF-Alpha production or inducing apoptosis of white blood cells by administering a pharmaceutically effective amount of purified, isolated quinic acid alkyl ester having a UV absorption at approximately 200 nm and a bioassay efficacy using IC50 in HL-60 cells of less than 100 micro grams per milliliter, where said amount is effective to inhibit TNF-Alpha production or to induce apoptosis of white blood cells where administration is other than topical.